Acting Within the Sepsis Golden Hour

In emergency medicine and intensive care units, sepsis is a leading cause of mortality where every hour of diagnostic delay directly compromises patient survival. Initiating the correct, targeted antimicrobial agent within the earliest window of presentation dramatically improves clinical outcomes. However, the standard median wait time of 48 hours for blood culture identification forces clinicians to rely blindly on broad-spectrum empirical antibiotics..

The Cube Dx direct blood test completely restructures this timeline, delivering complete pathogen identification and genetic resistance screening directly from raw EDTA blood in less than 3 hours.

Optimized for Vulnerable Patient Demographics

Critical care environments often face the challenge of limited or difficult sample collection, particularly in neonates, pediatric cohorts, elderly patients, or severely immunocompromised individuals.

• Low Input Volume:

While standard automated molecular instruments require significant sample draws, the Cube Dx GINA sample preparation protocols are fully optimized to work with ultra-low input thresholds ofonly 200µL to 500µL of raw whole blood.

Expedited Critical care Workflows

• Direct Whole-Blood Streamlining:

ER and ICU staff can order a direct whole-blood draw, bypass the standard culture incubation delay, and receive an actionable molecular diagnostic report detailing the specific causing organism within a single shift.

• Ultra-Fast Backup to MALDI-TOF:

For critical samples already processing within blood culture bottles, the extraction-free LINA protocol handles positive hemocultures in under 2 hours. It serves as a rapid backup system to MALDI-TOF, confirming fastidious slow-growers in parallel without waiting for pure culture plating.

Real-Time Resistance Profiling

Managing severe infections effectively requires knowing not just what the pathogen is, but also what drugs it resists. Cube Dx loops highly specific antibiotic resistance multiplex loops directly into its tracking screen to flag critical hospital-acquired threats instantly:

• Gram-Positive Threats:

Immediate detection of mecA/mecC (Methicillin-resistant Staphylococcus aureus/MRSA) and vanA/vanB (Vancomycin-resistant Enterococcus/VRE).

• • Gram-Negative Superbugs:

Accelerated detection of broad-spectrum carbapenemases and beta-lactamases including NDM, VIM, IMP, KPC, CTX-M Group 1), OXA48, AmpC, and mcr-1.